Undocumented and mixed-status families, in which some, but not all members have an undocumented immigration legal status, often face multiple and chronic stressors that influence their health. Compounded by trauma and limited opportunities, the aforementioned stressors negatively impact the physical and mental health of the undocumented and mixed-status population. This article uses a social determinants of health (SDOH) framework, examining five key domains––economic stability, education, healthcare, the social and community context, and the neighborhood and built environment. Undocumented immigrants face challenging living, social and work environments, have less economic stability, and have restricted access to opportunities. The aforesaid challenges place undocumented and mixed-status families at risk. Strategies are discussed to improve the health outcomes of this vulnerable population.