This paper features an intersectional SWOT analysis conducted at a minority-serving institution within a US Midwest urban setting, to inform the development of harm-reduction services for racial/ethnic sexual gender minority young adults. Our findings revealed the nuances of structured inequities, environmental challenges that are directly linked to access to resources and reduced opportunities to socialize within affirming spaces for racial/ethnic sexual gender minority young adults. The consequence is that those realities influenced their health and wellbeing. Our revelations rationalized the value of culturally-appropriate harm-reduction services and affirmed the distinct realities of racial/ethnic sexual gender minority young adults within the urban university setting.